Diagnosing mesothelioma

The diagnosis of m? Soth? Liom is often difficult because symptoms? My are similar? those of a number of other conditions. The diagnosis begins with a review of the patient \ 'm history? Union. A history of exposure? Asbestos May increase clinical suspicion for m? Soth? liom. A physical examination is r? Alis? E, followed by chest X-ray and often lung function tests. R X-rays? V? May slow? Grazed pleural common? Ment observ? E apr? S exposure? asbestos and the increasing suspicion of m? Soth? liom. A CT (or CAT) scan or MRI is g? N? Generally performed? E. If a large quantity? of liquid is pr? sent, the abnormal cells in May? tre d? tect? by cytology if this fluid is aspirated? with a syringe. For pleural fluid this is r? Alis? by a pleural drain or chest, in the ascites or a paracent? is ascitic drain and in a? panche p? ricard with pericardiocentesis. Although the absence of malignant cells? cytology does not completely exclude the m? Soth? liom, it makes it much more unlikely, especially if another diagnosis can? be made (eg tuberculosis, heart failure).

If cytology is positive or a plaque is regarded? R? as suspected, a biopsy is n? necessary to confirm a diagnosis of m? Soth? liom. M? Doctor removes one? Chantillon of tissue for examination under a microscope by a pathologist. A biopsy in May? Tre r? Alis? diff? rentes fa? ons, depending on location o? is abnormal. If the cancer is in the chest, m? May doctor perform a thoracoscopy. In this trial lasts, m? Doctor makes a small cut? through the chest wall and puts a thin tube? clear? appeal? thoracoscopy in the chest between two c? tes. Thoracoscopy allows the m? Doctor to examine the Internal inside the chest and obtain? Chantillon tissues.

If the cancer is in the abdomen, m? May doctor perform a laparoscopy. To obtain tissue for examination, the m? Doctor makes a small incision in the abdomen and ins? Re an instrument in the cavity? abdominale. If these proc? Procedures do not produce enough tissue, more extensive diagnostic surgery in May is n? Necessary.

Immunohistochemistry r? Typical results
Positive N? Ative
EMA (epithelial membrane antigen) CEA (Antig? Not carcinoembryonic)
WT1 (Wilms \ 'tumor 1) B72.3
Calretinin MOC-3 1
Mesothelin-1 CD15
Cytok? Ratin 5 / 6 Ber-EP4
HBME-1
(cells m? Soth? CNPF 1) TTF-1 (thyroid transcription factor-1)